Predicting Alcohol Use and Alcohol Use Disorder Symptoms From Subjective Responses to Alcohol in a Laboratory Social Setting
Overview
- Phase
- Early Phase 1
- Intervention
- Alcohol
- Conditions
- Alcohol Drinking
- Sponsor
- Carnegie Mellon University
- Enrollment
- 782
- Locations
- 1
- Primary Endpoint
- Change from Baseline Alcohol Use at 12-months
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
This study aims to identify risk factors that prospectively predict alcohol problems in young adults.
Detailed Description
The vast majority of alcohol use takes place in social settings, yet nearly all human experimental work has administered alcohol to individuals in isolation. This study will examine the effects of alcohol in social groups and test whether these responses predict the escalation of alcohol use and development of alcohol use disorder symptoms. Participants will also complete smartphone surveys querying subjective responses to alcohol in their daily lives. N=400 male and female young adults will participate in a laboratory session with two other participants and will consume either a moderate dose of alcohol or placebo beverage. Subjective and objective responses to alcohol will be assessed. Participants will also complete surveys on their smartphones; these will occur during drinking episodes and at random times throughout the day. Follow-up sessions will occur at 6-months and 12-months, to collect information about drinking habits and potential alcohol-related problems.
Investigators
Kasey Creswell
Associate Professor
Carnegie Mellon University
Eligibility Criteria
Inclusion Criteria
- •21 to 29 years of age
- •currently drinks alcohol
- •owns a smartphone
Exclusion Criteria
- •\[Exclusion criteria are masked from public viewing until data collection is complete. Please contact project managers.\]
Arms & Interventions
Alcohol Beverage
Moderate dose of alcohol (target BAC .08%)
Intervention: Alcohol
Placebo Beverage
Intervention: Placebo
Outcomes
Primary Outcomes
Change from Baseline Alcohol Use at 12-months
Time Frame: 12-month follow-up
Timeline Follow Back Method
Change from Baseline Alcohol Use Disorder Symptoms at 12-months
Time Frame: 12-month follow-up
Structured Clinical Interview for DSM-5
Secondary Outcomes
- Social Bonding(1 day (laboratory session))
- Alcohol Use(21-day ambulatory assessment period)
- Subjective Responses to Alcohol(1 day (laboratory session) and 21-day ambulatory assessment period)
- Mood(1 day (laboratory session))