TCTR20180316007已完成不适用
The Role of Quantitative Hepatitis B surface antigen, Hepatitis B core related antigen and Hepatitis B RNA in Prediction of Hepatitis B Relapse after Nucleos(t)ides Analogues Discontinuation in Chronic Hepatitis B.
Faculty of Medicine, Prince of Songkla University0 个研究点目标入组 92 人开始时间: 2018年3月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
研究概览
简要总结
The combined hepatitis B core-related antigen and hepatitis B virus RNA assays at end of treatment were highly predictive of subsequent clinical relapse. These novel biomarkers could potentially be used to identify patients who could safely discontinue nucleos(t)ide analogue therapy.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •Patients 18 years of age and older
- •- Receiving treatment with nucleos(t)ide analogue
- •- Meet the standard stopping criteria of of the 2015 update of APASL clinical practice guideline
排除标准
- •The sample did not include patients with advanced fibrosis or cirrhosis, defined as liver stiffness measured by transient elastography as 11 kPa or more or as Meta-analysis of Histological Data in Viral Hepatitis (METAVIR) stage 3 or higher on liver biopsy, or in whom imaging showed evidence of cirrhosis within the previous 6 months and at baseline before NA initiation. The sample also did not include patients with active hepatocellular carcinoma or other malignancies, those with co-infection with hepatitis C virus or human immunodeficiency virus, those undergoing concomitant treatment with immunosuppressive agents, those with other chronic liver disease, pregnancy or lactating women and patients who refused to participate in the study.
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