CTRI/2024/07/071699尚未招募不适用
Evaluation of plasma microRNA-21 for Early Detection of Postoperative Acute Kidney Injury in patients undergoing exploratory laparotomy: A Prospective Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Blood level of preoperative mi-RNA-21-5p and risk of post operative AKI progression.
研究概览
简要总结
We will collecting baseline samples pre operatively from the eligible patients after obtaining written informed consent, patient will be induced as per the standard anaesthesia protocol, 4 hours after the surgery, another sample for miRNA will be obtained and the patient will be followed up on day 3 and day 7 after the surgery for the assessment and follow up for AKI
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •American Society of Anesthesiologists (ASA) Physical Status (PS) IE & IIE.
排除标准
- •Pre-existing renal dysfunction.
- •Patient presenting for redo surgery or surgery due to blunt or penetrating trauma.
- •Patients with preoperative altered mental status, hemodynamic instability or respiratory distress.
结局指标
主要结局
Blood level of preoperative mi-RNA-21-5p and risk of post operative AKI progression.
时间窗: 4 hours after surgery.
次要结局
- Blood levels of preoperative miRNA-146-5p and risk of Postoperative AKI progression.(4 hour after surgery)
- Association of miRNA levels and severity of AKI(4 hours after surgery.)
研究者
Dr Sukhyanti Kerai
Maulana Azad Medical College.
研究点 (1)
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