Bispectral Index as an Analgesia Monitoring in Severely Ill Patient: Effect of Remifentanyl
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- Assistance Publique - Hôpitaux de Paris
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- BIS variation during bronchoalveolar lavage
- Last Updated
- 20 years ago
Overview
Brief Summary
The aim of this protocol is to study the prophylactic effect of remifentanil on bispectral index variation during a nociceptive stimuli.
Detailed Description
Pain is difficult to estimate in ICU because most of the patients are sedated. Bispectral index could be helpful in detecting this pain in ICU patients. Remifentanil is a morphinomimetic product with short half life that could be interesting for short nociceptive stimuli, as bronchoalveolar lavage. The purpose of this study is to evaluate the impact of remifentanil infusion on bispectral index (BIS) variations during bronchoalveolar lavage. It is a prospective, double blind study, versus placebo on 40 sedated and critically ill patients. The hypothesis is that BIS can study analgesia in sedated patient.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sedated patient with mechanical ventilation with suspected nosocomial pneumonia
Exclusion Criteria
- •Pace maker
- •Neurologic illness
- •Hemodynamic instability
- •Hypothermia
Outcomes
Primary Outcomes
BIS variation during bronchoalveolar lavage
Secondary Outcomes
- Systolic blood pressure, diastolic blood pressure, heart rate viation