Effects of Normobaric Hypoxia and Different Exercise Modes on Blood Glucose Regulation in Overweight Adults

Not Applicable

Completed

• Conditions: Healthy; Physical Inactivity; Overweight
• Interventions: Other: Low-moderate intensity exercise; Other: Control; Other: Sprint interval training; Other: Functional exercise

• Registration Number: NCT05627804
• Lead Sponsor: Swinburne University of Technology

Brief Summary

Obesity is a major global health issue and a primary risk factor for metabolic-related disorders. While physical inactivity is one of the main contributors to obesity, it is a modifiable risk factor with exercise training as an established, non-pharmacological treatment to prevent the onset of metabolic-related disorders, including obesity. Exposure to low-oxygen availability (hypoxia) via normobaric hypoxia (simulated altitude via reduced inspired oxygen fraction), termed hypoxic conditioning, in combination with exercise has been increasingly shown in the last decade to enhance blood glucose regulation and decrease body mass index, providing a feasible strategy to treat obesity.

However, findings from studies investigating the potential for hypoxia to augment the exercise training response and subsequent metabolic health are equivocal. Notably, there is a lack of information regarding the optimal combination of exercise variables and hypoxic severity to enable an individualized and safe practice of exercising in a hypoxic environment.

In the present randomized, single-blind, cross-over study, the investigators will investigate the effects of single-bout of different exercise modes under moderate hypoxia (FiO2, 16.5%).

The investigators hypothesize that all exercises combined with hypoxia improve glucose homeostasis in overweight individuals.

Detailed Description

In the present randomized, single-blind, cross-over study, participants will be exposed to moderate hypoxia (oxygen level 16.5%) during three different exercises (low-intensity cycling, sprint interval and functional exercises). Participants will be randomly assigned to each exercise condition (computer-generated randomization plan), separated by a washout period (5-7 days). To accomplish this, participants will exercise in an environmental chamber in which oxygen concentration of the ambient air and, as such, oxygen levels can be closely controlled and monitored.

Participants are required to attend the laboratory 8 times. These visits are including pre-exercise screening, baseline blood sampling, body composition screening and exercise in altitude conditions.

Study Timeline

• Study First Submitted: 2022-11-13
• Study First Submitted QC: 2022-11-21
• Study First Posted: 2022-11-28
• Study Start: 2023-01-03
• Primary Completion: 2023-06-30
• Study Completion: 2023-08-01
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-20
• Last Update Posted: 2023-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 13

Inclusion Criteria

• BMI is between 25-29 kg/m²
• Physical inactive (physical activity <150 min/week)
• No known heart or metabolic diseases (such as Type 2 diabetes)
• Not currently taking any prescribed medication
• No reported musculoskeletal injuries recently
• Not exposed to hypoxia >1000 m prior to the study

Exclusion Criteria

• Impaired glucose tolerance (2 hour glucose: >7.8 - 11.1 mmol/L)
• Type 2 diabetes mellitus
• Obstructive sleep apnea
• Chronic obstructive pulmonary disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Moderate hypoxia	Low-moderate intensity exercise	The participant will perform different exercise modes under moderate hypoxia (fraction oxygen: 16.5%). Blood samples immediately after exercise oral glucose tolerance test will be collected.
Control normoxia	Control	The participant will not perform any exercise under normoxia and moderate hypoxia. Blood samples of oral glucose tolerance test will be collected.
Moderate hypoxia	Functional exercise	The participant will perform different exercise modes under moderate hypoxia (fraction oxygen: 16.5%). Blood samples immediately after exercise oral glucose tolerance test will be collected.
Moderate hypoxia	Sprint interval training	The participant will perform different exercise modes under moderate hypoxia (fraction oxygen: 16.5%). Blood samples immediately after exercise oral glucose tolerance test will be collected.

Primary Outcome Measures

Name	Time	Method
Oral glucose tolerance test (glucose)	Change of fasting and postprandial plasma glucose concentrations compared to different exercise mode at immediately after exercise	Change of plasma glucose concentration immediately post-exercise under different exercise modes
Oral glucose tolerance test (insulin)	Change of fasting and postprandial plasma insulin concentrations compared to different exercise mode at immediately after exercise	Change of plasma insulin concentration immediately post-exercise under different exercise modes

Trial Locations

Locations (1)

National Sports Institute of Malaysia; 🇲🇾 Kuala Lumpur, Malaysia