Effects Of Walnut-Enriched Diet On Blood Lipids And Glucose Profiles In Hyperlipidemic Subjects: A Randomized-Controlled Trial: A Randomized-Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 37
- Primary Endpoint
- Reduction in serum lipids and fasting glucose levels
Study Overview
Brief Summary
Walnuts have been shown to reduce serum lipids in hyperlipidemic individuals with a well-controlled feeding trials. Current study have been determined the effects of daily walnut consumption on serum lipids, fasting glucose and insulin levels in hyperlipidemic individuals.
Detailed Description
In this, randomized controlled trial, mild to moderate hyperlipidemic subjects were randomly divided into 2 groups as walnut-enriched (n=20) and control (n=17) groups for 6 weeks. All subjects adhered to a medical nutrition therapy as low-fat and low-cholesterol diet. The walnut-enriched group was supplemented with 40 g/day of walnuts added to their diets. In order to follow nutritional status of subjects, they were visited every 15 days (in total 4 times). Anthropometric measurements of the subjects were taken and were monitored at each visit during the study. Blood samples were measured at the beginning and again at the end of the study.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 30 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Hyperlipidemic patients who are not using any lipid lowering medications
- •Non-smoker
- •No alcohol consumption
- •Individuals who are having ≤30kg/m2
- •Individuals who do not have any allergy for nut consumption
- •Female participants who are not pregnant or breastfeeding
- •Individuals should not be in a weight loss programme
- •Having not consumed regular nuts for the last 1 month,
- •Except hypertension, they should not have other chronic diseases (such as diabetes, chronic renal failure)
- •No intense exercise
Exclusion Criteria
- •Failure to meet the criteria for inclusion criteria.
Arms & Interventions
Control Group
In 'Control group' participants had 6 week follow-up without any intervention.
Interventional Group
In 'Interventional group' participants had 6 week follow-up and during that period of time, they were asked to consume 40g/day walnut. Participants in intervention group was ensured to consume all 40g of walnut every day, during their snack times for 6 weeks.
Intervention: Walnut-enriched Group (Dietary Supplement)
Outcomes
Primary Outcomes
Reduction in serum lipids and fasting glucose levels
Time Frame: Six weeks
In both group, participants have decreased serum total cholesterol and LDL-cholesterol.However especially walnut-enrcihed group significantly changed fasting glucose and insulin levels.
Secondary Outcomes
No secondary outcomes reported
Investigators
Gözde Okburan
Senior Instructor
Eastern Mediterranean University