Epilepsy surgery evaluation in patients with refractory epilepsy: prospective application of routine genetic testing

Recruiting

Conditions: Epilepsy
Focal epilepsy
Hersenaandoeningen
Epilepsie

Registration Number: NL-OMON46823

Lead Sponsor: eurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 275

Inclusion Criteria

Cohort I
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
o The patient enters the presurgical evaluation program in one of the participating centers
o No age limit
o Patients and/or parents/legal representative are willing and able to give informed consent for participation in the study.
o MRI-brain shows no abnormalities that are likely to be causative for the epilepsy (*MRI-negative*: As determined by the local neuroradiologist and MD team, independent of the used MR imaging protocol, field strength, or post-processing.);Cohort II
o The patient entered the presurgical evaluation program in in the UMC Utrecht
o No age limit
o Patients and/or parents/legal representative are willing and able to give informed consent for participation in the study
o The patient underwent surgery in the UMC Utrecht for drug-resistant FE and had MCD, GNT, or negative pathology

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
o No age exclusion criteria
o Known genetic disorders at entry that are directly related to the patient*s epilepsy; genetic disorders not related to the epilepsy are not a reason for exclusion, however such conditions will be noted in the participant*s research file.