Study of the treatment of children and adolescents with diffuse brainstem tumors using Valproic Acid with Chemotherapy and Radiation Therapy

Phase 2

Withdrawn

• Conditions: Glioma, brain stem neoplasm; C04.557.465.625.600.380; C04.588.614.250.195.411.100

• Registration Number: RBR-7ygspd
• Lead Sponsor: Hospital Infantil Albert Sabin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-30
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients between 0 and 18 years diagnosed with DIPG by imaging. Absence of acute cerebral bleeding. It includes subdural hematoma, subarachnoid and intraparenchymal bleeding. No prior treatment with chemotherapy or radiotherapy.

Exclusion Criteria

History of recent head trauma. Coma with brain herniation. Coagulopathy (platelet counts <50,000 / mm3, INR> 1.8). Previous recent use of valproic acid. Use of other anti-convulsant drugs.

Study & Design

• Study Type: Intervention
• Study Design: Not specified