Combined Effect of Preoperative Dexamethasone and Intraoperative Paracetamol on Postoperative Sore Throat for Patients Undergoing Urologic Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 242
- 试验地点
- 1
- 主要终点
- Postoperative sore throat
研究概览
简要总结
The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.
详细描述
The postoperative sore throat is a common complication after the general anesthesia which decreases the quality of life. Dexamethasone is known to effective for the prevention of postoperative sore throat. The combined effect of the dexamethasone and paracetamol for postoperative sore throat, however, is not investigated.
The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for urologic surgery under general anesthesia
- •ASA I-III
排除标准
- •Patients with recent sore throat
- •Patients with neck surgery
- •Patients with anticipated difficult airway
- •Patients with Mallampati grade 3
- •Patients with severe cardiovascular or pulmonary disease
- •Patients with allergic history to dexamethasone or paracetamol
- •Patients with liver function disorder
- •Patients with liver disease
研究组 & 干预措施
Dexamethasone
Dexamethasone will be administered 30 minutes before the anesthetic induction.
干预措施: Dexamethasone (Drug)
Dexamethasone+ Paracetamol (DP)
Dexamethasone will be administered 30 minutes before the anesthetic induction. Paracetamol will be administered at the end of the surgery.
干预措施: Dexamethasone (Drug)
Dexamethasone+ Paracetamol (DP)
Dexamethasone will be administered 30 minutes before the anesthetic induction. Paracetamol will be administered at the end of the surgery.
干预措施: Paracetamol (Drug)
结局指标
主要结局
Postoperative sore throat
时间窗: 1 hour postoperatively
Postoperative sore throat after 1 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe)
次要结局
- Postoperative pain(0, 1, 6, 24 hour postoperatively)
- Vomiting(0, 1, 6, 24 hour postoperatively)
- Postoperative sore throat degree(0, 1, 6, 24 hour postoperatively)
- Nausea(0, 1, 6, 24 hour postoperatively)
- Somnolence(0, 1, 6, 24 hour postoperatively)
- Headache(0, 1, 6, 24 hour postoperatively)
- Hoarseness(0, 1, 6, 24 hour postoperatively)
- Dysphagia(0, 1, 6, 24 hour postoperatively)
- Postoperative sore throat(0, 6, 24 hour postoperatively)
- Shivering(0, 1, 6, 24 hour postoperatively)
- Analgesics(0, 1, 6, 24 hour postoperatively)