Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination, a Pilot Study and Proof of Concept
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Success rate and interpretability of images acquired in MRF
研究概览
简要总结
Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy).
The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters.
Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients' short and long-term vital and functional prognosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Subacute ischemic stroke patients (< 15 days after onset)
- •Middle cerebral artery or anterior cerebral artery territory stroke
- •Modified Rankin Scale (mRS) = 0-4
排除标准
- •* MRI contraindications
研究组 & 干预措施
Experimental
Every patient will perform classic brain MRI with additional MRF sequences.
干预措施: Achieva 3.0T dStream Philips (Device)
结局指标
主要结局
Success rate and interpretability of images acquired in MRF
时间窗: From enrollment to the end of the MRI exam
Assessment of the success rate and interpretability (subjective evaluation with Likert scales of very satisfactory, satisfactory, insufficient, or unacceptable)
次要结局
- Characterize and extract the physical parameters of the signal acquired with MRF.(From enrollment to the end of the MRI exam)