NCT00434226终止2 期
A Randomized, Controlled, Open-Label, Multicenter, Phase II Study of the Safety and Efficacy of Sunitinib in Combination With Bevacizumab, Carboplatin, and Paclitaxel in Previously Untreated Patients With Advanced Non-Small Cell Lung Cancer
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 56
- 主要终点
- Best Response
研究概览
简要总结
This is a Phase II, randomized, controlled, open-label, multicenter trial designed to provide a preliminary assessment of the safety and efficacy of sunitinib when combined with carboplatin and paclitaxel chemotherapy and bevacizumab in patients with locally advanced, recurrent or metastatic NSCLC who have not received prior systemic therapy for NSCLC. All patients will have advanced, histologically or cytologically confirmed NSCLC (Stage IIIb with pleural effusions, Stage IV, or recurrent).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed Informed Consent Form
- •Age ≥ 18 years
- •Advanced histologically or cytologically confirmed NSCLC (Stage IIIb with malignant pleural or pericardial effusion, Stage IV, or recurrent)
- •Measurable or non-measurable disease
- •Patients with treated brain metastases are eligible if there is no evidence of progression or hemorrhage after treatment, as ascertained by clinical examination and brain imaging (MRI or CT) during the screening period (brain imaging to be competed Day -7 to Day 1).
- •Prior treatment for CNS disease as deemed appropriate by the treating physician
- •ECOG performance status 0 or 1
- •Ability and willingness to comply with study and follow-up procedures
排除标准
- •Prior systemic chemotherapy for metastatic disease
- •Active malignancy other than lung cancer
- •Current, recent, or planned participation in another experimental drug study
- •Prior treatment with anti-VEGF agent or agents targeting similar pathways as sunitinib
- •Adjuvant chemotherapy or prior combined modality neoadjuvant therapy (chemotherapy plus radiotherapy with or without surgery) within 6 months prior to Day 1 of Cycle 1
- •Life expectancy of < 12 weeks
- •Current, recent, or planned participation in an experimental drug study
- •Inability to take oral medication or requirement of IV alimentation or total parenteral nutrition, or prior surgical procedures affecting absorption
- •Inadequate organ function
- •Known evidence of disseminated intravascular coagulopathy
- •Active infection or fever > 38.5°C within 3 days prior to Day 1 of Cycle 1
- •Untreated abnormal thyroid function tests as defined by institutional standards (patients with controlled hypothyroidism are eligible for study participation)
- •Any other medical condition(s) (including mental illness or substance abuse) deemed by the clinician to be likely to interfere with a patient's ability to provide informed consent, cooperate, or participate in the study, or to interfere with the interpretation of the results
- •Intrathoracic lung carcinoma of squamous cell histology
- •Known CNS disease except for treated brain metastases
- •Inadequately controlled hypertension
- •Prior history of hypertensive crisis or hypertensive encephalopathy
- •New York Heart Association (NYHA) Class II or greater CHF
- •History of myocardial infarction or unstable angina within 12 months prior to Day 1 of Cycle 1
- •History of stroke or transient ischemic attack within 12 months prior to Day 1 of Cycle 1
- •Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent peripheral arterial thrombosis within 6 months prior to Day 1 of Cycle 1
- •History of hemoptysis within 1 month prior to Day 1 of Cycle 1
- •Evidence of bleeding diathesis or significant coagulopathy (in the absence of therapeutic anticoagulation)
- •Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 1 of Cycle 1 or anticipation of need for major surgical procedure during the course of the study
- •Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to Day 1 of Cycle 1
- •History of abdominal fistula or gastrointestinal perforation within 6 months prior to Day 1 of Cycle 1
- •Serious, non-healing wound, active ulcer, or untreated bone fracture
- •Proteinuria at screening, as demonstrated by a urine protein/creatinine ratio of ≥ 1.0 at screening
- •Known hypersensitivity to any component of bevacizumab or sunitinib
- •Pregnancy (positive pregnancy test) or lactation
研究组 & 干预措施
Bevacizumab + Carboplatin/Paclitaxel + Sunitinib
Experimental
干预措施: bevacizumab (Drug)
Bevacizumab + Carboplatin/Paclitaxel + Sunitinib
Experimental
干预措施: sunitinib (Drug)
Bevacizumab + Carboplatin/Paclitaxel + Sunitinib
Experimental
干预措施: carboplatin (Drug)
Bevacizumab + Carboplatin/Paclitaxel + Sunitinib
Experimental
干预措施: paclitaxel (Drug)
Bevacizumab + Carboplatin/Paclitaxel
Placebo Comparator
干预措施: bevacizumab (Drug)
Bevacizumab + Carboplatin/Paclitaxel
Placebo Comparator
干预措施: carboplatin (Drug)
Bevacizumab + Carboplatin/Paclitaxel
Placebo Comparator
干预措施: paclitaxel (Drug)
结局指标
主要结局
Best Response
时间窗: From randomization until disease progression/recurrence
The best overall response is the best response, per RECIST criteria, recorded from randomization until disease progression/recurrence (includes both confirmed and unconfirmed responses). Although the original primary outcome was progression-free survival, there was insufficient data available to report on that outcome.
次要结局
- Incidence of Adverse Events Leading to Sunitinib Discontinuation, Dose Interruption, or Dose Reduction(60 days following the last administration of study treatment)
- Incidence of Grade ≥ 3 Adverse Events(60 days following the last administration of study treatment)
- Serious Adverse Events(60 days following the last administration of study treatment)
- Incidence of Adverse Events Leading to Bevacizumab Discontinuation or Dose Interruption(60 days following the last administration of study treatment)
研究者
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