NL-OMON52813
Completed
Not Applicable
[18F]fluoro-PEG-folate PET/CT imaging in patients with epithelial ovarian cancer - [18F]fluoro-PEG-folate PET/CT imaging in epithelial ovarian cancer
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Epithelial ovarian cancer
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 15
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with radiologically FIGO stage IIIB/IIIC EOC based on the conventional
- •CT scan who are
- •scheduled to undergo primary cytoreductive surgery and
- •a) in whom EOC is histologically proven, or
- •b) in whom EOC is cytologically suspected and a serum CA125/CEA ratio \> 25 is
- •treated with neoadjuvant chemotherapy (NACT) and are scheduled to undergo
- •interval cytoreductive surgery and
- •a) in whom EOC is histologically proven, or
- •b) in whom EOC is cytologically suspected and a serum CA125/CEA ratio \> 25 was
- •found before NACT
Exclusion Criteria
- •1\. Women younger than 30 years of age (in accordance with the guidelines of the
- •Netherlands Commission on Radiation Dosimetry, as the total radiation dose will
- •be 7\.2 mSv)
- •2\. Patients who previously underwent primary laparotomy and in whom complete or
- •optimal cytoreduction was not considered feasible.
- •3\. Contraindication for PET (pregnancy, lactating or severe claustrophobia)
- •4\. Thrombocytopenia (platelet count \< 100 x 10^9/L) and/or INR \> 2
- •5\. Impaired renal function (defined as eGFR \< 50 mL/1\.73 m2\)
- •6\. Impaired liver function (ALT, AST or total bilirubin \> 3x upper limit of
- •7\. Clinically significant abnormalities on ECG and/or clinically laboratory
Outcomes
Primary Outcomes
Not specified
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