Investigation of the predictive value of coagulation parameters for the course of disease in COVID-19 patients

• Conditions: U07.1; COVID-19, virus identified

• Registration Number: DRKS00021574
• Lead Sponsor: Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-19
• Study Completion: 2022-02-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 480

Inclusion Criteria

at least 18 years old
- hospitalisation with suspected or confirmed COVID-19 diagnosis

Exclusion Criteria

-younger than 18 years

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood sampling (6 ml Plasma) at day 1 and 7 of hospitalization: determination of Quick, PTT, fibrinogen, D-dimer, antithrombin, hs-troponin, coagulation factors und VWF-antigen, Protein C und Protein S, thrombin generation, plasminogen-activator inhibitor-Type 1

Secondary Outcome Measures

Name	Time	Method
-clinical symptoms<br>-type and duration of antikoagulation<br>-Therapy (medication, heparin, oxygen, NIV/IV, ECLS)<br>-duration of hospitalization<br>-Outcome (morbidity, mortality)<br>-Co-morbidities and medication<br>Additional data will be documented in CRF about:<br>sex, age, secondary infections (viral, bacterial), SOFA Score, small blood count, CRP