ate neonatal neurological outcome in infants with prenatally diagnosed duct dependent CHD and its relation with fetal and neonatal cerebral perfusio
Completed
- Conditions
- congenital heart defectheart disease1001039410028920
- Registration Number
- NL-OMON40142
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
Mothers of fetusses suspected of CHD and their subsequent newborn infant with duct dependent congenital heart defect
Gestational age > 35 weeks
Exclusion Criteria
Large congenital cerebral malformation
Severe chromosomal defect
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Qualitative assessment of GMs according to Prechtl*s method. In addition, we<br /><br>will obtain motor optimality scores for more detailed analysis of the GMs;</p><br>
- Secondary Outcome Measures
Name Time Method <p>Near-infrared Spectroscopy: cerebral (rcSO2) and systemic (rrSO2) oxygen<br /><br>saturation and FTOE;<br /><br>Pulsatility index (PI) and if possible maximum velocity of various arterial<br /><br>vessels, measured with Doppler ultrasound.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link cerebral perfusion to neonatal neurological outcomes in duct-dependent CHD infants?
How does fetal cerebral perfusion in duct-dependent CHD compare to standard-of-care outcomes for similar congenital heart defects?
Are there specific biomarkers that correlate with cerebral perfusion patterns in prenatally diagnosed duct-dependent CHD cases?
What adverse events are associated with compromised cerebral perfusion in neonates with congenital heart disease?
What combination therapies or interventions are being explored to improve cerebral perfusion in duct-dependent congenital heart defects?