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Assessment of THL and Potential Risk of Hypothyroidism in Healthcare Workers Exposed to Low-dose Ionizing Radiation

Active, not recruiting
Conditions
Hyperthyroidism
Registration Number
NCT07048548
Lead Sponsor
Superior University
Brief Summary

"This study is designed to evaluate the thyroid health of healthcare workers exposed to low-dose ionizing radiation at INMOL Cancer Hospital, Lahore. Specifically, it investigates whether prolonged occupational exposure in radiology and nuclear medicine departments is associated with altered thyroid hormone levels or an increased risk of hypothyroidism. The thyroid gland is highly sensitive to radiation, and existing literature suggests a possible link between occupational exposure and thyroid dysfunction.

Detailed Description

A cross-sectional research design will be used over a four-month period. A sample of 44 participants will be selected using purposive sampling from the hospital's radiology and nuclear medicine staff.

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
44
Inclusion Criteria
  • Staff members from radiology and nuclear medicine departments who meet both conditions.
  • workplace experience exceeding one year
  • age between 20 to 40 will be selected for this study.
Exclusion Criteria
  • Employees who have worked less than twelve months
  • pregnant participants.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
thyroid function assessment12 Months

Thyroid function is assessed through blood tests, primarily measuring TSH (Thyroid Stimulating Hormone), T4 (Thyroxine), and sometimes T3 (Triiodothyronine) levels. Abnormal levels of these hormones can indicate an underactive (hypothyroidism) or overactive (hyperthyroidism) thyroid.

Normal Ranges (approximate):

TSH: 0.4 - 4.0 mIU/L Free T4: 0.7 - 1.9 ng/dL Total T4: 5.0 - 12.0 μg/dL Total T3: 80 - 220 ng/dL

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

INMOL hospital

🇵🇰

Lahore, Punjab, Pakistan

INMOL hospital
🇵🇰Lahore, Punjab, Pakistan

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