Characterization of Cancer Tissue Using 3D Biosynthetic Material

• Conditions: Cancer

• Registration Number: NCT02678078
• Lead Sponsor: Technion, Israel Institute of Technology

Brief Summary

Characterization of Cancer Tissue Using 3D Biosynthetic Materials. Using liver biopsy from stage 4 cancer patients, the investigators will evaluate and characterize the metastatic cells.

Detailed Description

The investigators' biomaterial lab has developed an in vitro diagnostic system in which a cancer tumor is placed inside a 3D hydrogel. This material has similar properties to the human tissue and can visualize cell migration and proliferation. In this system, the investigators have already characterised human metastatic cells obtained from nude mice tumors. The diagnostic assay is able to evaluate the reduction in cell growth associated with anti-cancer drug therapy. The next step is to test the in vitro diagnostic system using human tissue samples from human patients, and to validate the system as a simple and effective a priori diagnostic tool for characterizing patient tumours.

Study Timeline

• Study Start: 2016-02
• Study First Submitted: 2016-02-04
• Study First Submitted QC: 2016-02-08
• Study First Posted: 2016-02-09
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-05
• Last Update Posted: 2016-05-06
• Primary Completion: 2018-01
• Study Completion: 2018-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• liver tumor

Exclusion Criteria

• refuse to volunteer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cell growth	1 week	biopsy will be placed inside 3D gel, and growth will be measured over 1 week time.

Trial Locations

Locations (1)

Rambam; 🇮🇱 Haifa, Israel