Evaluation of the effect of Upanaha treatment with Vachadi Upanaha Churna in Osteoarthritis (OA Knee) wrt pain and stiffness of joints - Upanaha

Central Council For Research in Ayurvedic Sciences0 个研究点目标入组 30 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1.Patients of either sex aged between 35 and 65 years.
•2.Subjects having VAS score for knee pain between 45-74 mm (moderate pain)
•3.Clinical and radiological evidence of Osteoarthritis knee (Unilateral/ bilateral) as per ACR criteria
•(i)knee pain,
•(ii)at least one of three
•(a)Age > 50 years
•(b)stiffness < 30 minutes
•(c)Crepitus
•(iii)Osteophytes
•4.Radiographical changes as per Grade I to III of Kellgren& Lawrence Radiological scale
•5.Able and willing to participate and provide signed informed consent

•1.Patients with Grade IV Kellgren& Lawrence Radiological scale
•2.History of any trauma/ fractured joint / surgical/diagnostic intervention with reference to the affected joint(s).
•3.H/O monoarthritis/ polyarthritis other than Osteoarthritis Knee such as gouty arthritis, rheumatoid arthritis and psoriatic arthritis etc.
•4.Any unstable cardio-vascular disease.
•5.Patients with uncontrolled Hypertension ( >160/100 mmHg)
•6.Patients with uncontrolled Diabetes Mellitus having HbA1C >7.5%
•7.Patients with evidence of malignancy.
•8.Patients with any concurrent hepatic disorder (defined as liver enzymes SGOT/SGPT >2 times upper normal limit) or Renal Disorders (defined as S.Creatinine >1.4mg/dl) or Pulmonary Dysfunction
•9.The patient has been administered any chondroprotective drugs, intra-articular injection into the affected joint or systemic medication with corticosteroids during the preceding 3 months.
•10.Pregnant / lactating woman.
•11.Patients who are currently participating in any other clinical trial.
•12.Any other condition which the Principal Investigator thinks may jeopardize the study.

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