NCT00139555已完成4 期
Effects of Amlodipine/Benazepril in Reducing Left Ventricular Hypertrophy in Patients With High Risk Hypertension
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- Novartis
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Change from baseline in left ventricular mass index after 52 weeks
研究概览
简要总结
Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbidity and mortality in patients with high blood pressure, compared to those without LVH. Reduction of left ventricular mass (LVM) with antihypertensive agents is associated with improved clinical outcome. This study will evaluate the effects of amlodipine/benazepril in reducing LVM in patients with high risk hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males or female patients ≥ 55 years of age
- •LVH as confirmed by echocardiogram
- •Patients with high risk hypertension, currently treated or already taking antihypertensive medication
排除标准
- •Renal artery stenosis
- •Symptomatic heart failure or known ejection fraction < 40%
- •Myocardial infarction or stroke within 6 months
- •Presence of cranial aneurysm clips, coronary artery metal stents and pacemakers
- •Pregnant or lactating females
- •Cancer within the last 5 years
结局指标
主要结局
Change from baseline in left ventricular mass index after 52 weeks
次要结局
- Change from baseline in aorta function assessed blood pressure measurements after 52 weeks
- Change from baseline in left ventricular mass after 52 weeks
- Change from baseline in diastolic function after 52 weeks
- Change from baseline in markers of fibrosis and increased heart size after 52 weeks
研究者
研究点 (1)
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