Comparison of Oral versus Injectable Iron Chelation Therapy in Reducing Serum Ferritin Levels in Patients with Transfusion Dependent Thalassemia
Phase 3
Recruiting
- Conditions
- Beta thalassemia.Beta thalassemiaD56.1
- Registration Number
- IRCT20221231056999N2
- Lead Sponsor
- DHQ Teaching Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Presenting with beta thalassemia major (defined as group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains in blood causes severe, transfusion-dependent anemia).
Patients who are transfusions dependent with serum ferritin level >2000 ng/ml.
Exclusion Criteria
Children already taking trial treatment (as per medical record).
Children with liver failure (ALT & AST >50IU).
Children having anemia (hemoglobin level <10 g/dl)
Children who will lose during follow ups.
Parents/Guardian refused the participation of their child.
Stoppage of medicine due to side effects/compliance.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum ferritin level. Timepoint: Assessed at baseline and after 6 months of therapy. Method of measurement: Blood sample will be taken by using 3cc disposable syringe and sent to the laboratory of the hospital for assessment of serum ferritin level using standard laboratory protocols.
- Secondary Outcome Measures
Name Time Method