Assessment of radiation dose reduction and image quality of single acquisition, two contrast-injection computed tomography chest/abdomen/pelvis scans compared to the standard two phase imaging protocol for disease staging of oncology patients.

Not Applicable

Completed

• Conditions: CT radiation dose; Other - Research that is not of generic health relevance and not applicable to specific health categories listed above

• Registration Number: ACTRN12613000820707
• Lead Sponsor: The Alfred

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

1) Referred oncology patients undergoing staging contrast enhanced CT chest/abdomen/pelvis who have had previous CT chest/abdomen/pelvis imaging performed within 1 year.
2) Only adult patients (age >/= 18) will be imaged using the proposed protocol.
3) Only outpatients will be included in the study.
4) Signed informed consent form.

Exclusion Criteria

1. Oncology patients referred for non-enhanced CT chest/abdomen/pelvis for any reason and including contrast allergy and renal failure.
2. Severe heart failure (this can impair adequate tissue contrast enhancement).
3. Extensive progression of cancer in the period between the two scans. This could prevent direct comparison image quality of the two scans.
4. Pregnancy.
5. Inability to sign own consent (intellectual or mental impairment).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure of the radiation dose reduction of a single pass chest/abdomen/pelvis CT protocol in oncology patients compared to a standard two stage arterial and venous phase imaging protocol.<br>Effective doses are calculated by multiplying a dose-length product (DLP) and a constant called Edlp. <br>DLP is provided by CT software and recorded for every CT scan performed. <br>Edlp depends on the region of body scanned but constant for that region and the type of CT scanner used.[At the time of performing the scan.];Evaluation of the diagnostic image quality of a single pass chest/abdomen/pelvis CT protocol assessed by the Regions of Interest (ROI’s) measure of the degrees of enhancement (attentuation) in the descending aorta and mid liver[At the time of performing the scan.]

Secondary Outcome Measures

Name	Time	Method
Time per scan[At the time of performing the scan.];Ease of performing the scans (qualitative assessment by radiographers)[At the time of performing the scan.]