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Clinical Trials/NCT07448467
NCT07448467
Recruiting
Not Applicable

Investigating the Effectiveness of Progressive Resistance Exercise Training in the Management of Lymphedema Developing After Breast Cancer Treatment: a Randomized Controlled Trial

Uskudar University1 site in 1 country50 target enrollmentStarted: March 6, 2026Last updated:
Interventionscontrolexercise

Overview

Phase
Not Applicable
Status
Recruiting
Sponsor
Uskudar University
Enrollment
50
Locations
1
Primary Endpoint
LYMphedema Quality of Life

Overview

Brief Summary

This study aims to investigate the effect of progressive resistance exercise training on the clinical findings and functional outcomes of lymphedema in individuals who develop upper extremity lymphedema after breast cancer treatment (surgery, chemotherapy and/or radiotherapy).

Detailed Description

The study is designed as a randomized controlled trial. Volunteers participating in the study will consist of individuals who have developed lymphedema after breast cancer and who agree to participate in the study. Volunteer female participants will be divided into 2 groups of equal numbers. Participants in the control group will receive lymphedema treatment, while participants in the exercise group will perform progressive resistance upper extremity exercises at home, 2 days a week for 12 weeks. All exercises will be performed with compression bandages. All participants will be evaluated before and after treatment using a hand dynamometer, the Disabilities of the Arm, Shoulder and Hand Scale, and the Lymphedema Quality of Life Questionnaire-Arm.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
Single (Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Being between 18 and 60 years of age.
  • Being included in the study 3 months after undergoing surgery.
  • Being able to tolerate compression bandages or compression garments.

Exclusion Criteria

  • \- Individuals who need to restart active cancer treatment during the study period. - Being within the first 3 months after surgery.

Arms & Interventions

control group

Active Comparator

They will receive classic lymphedema physiotherapy.

Intervention: control (Other)

exercise group

Experimental

In addition to classic lymphedema physiotherapy, a progressive resistance exercise training program will be implemented.

Intervention: control (Other)

exercise group

Experimental

In addition to classic lymphedema physiotherapy, a progressive resistance exercise training program will be implemented.

Intervention: exercise (Other)

Outcomes

Primary Outcomes

LYMphedema Quality of Life

Time Frame: 14 weeks

The Lymphedema Quality of Life Questionnaire, a validated disease-specific QoL tool, was also administered at baseline and at day 28. Overall QoL is scored on a single item by the patient on a scale of 1-10.

Disabilities of the Arm, Shoulder and Hand

Time Frame: 14 weeks

Validated outcome measure that asks an individual to self-report about the ability to perform certain upper limb activities. Questions are responded on a 5-point Likert scale.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Uskudar University
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Doç.Dr.Ömer Şevgin

Assoc.Prof.Dr.

Uskudar University

Study Sites (1)

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