Walking the Isobole of drug Interaction: Comparison of hemodynamic effects, cerebral and tissue oxygenation for 4 equipotent combinations of propofol and remifentanil

Completed

Conditions: anesthesie
general anaesthesia

Registration Number: NL-OMON40328

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

- General anesthesia required for the procedure
- Age: 18 years and older
- American Society of Anesthesiologists (ASA) physical status I to III
- Written informed consent

Exclusion Criteria

- Refusal to participate in this study
- Contra-indications for the use of propofol or remifentanil
- BMI > 35 kg/m2
- Central nervous system disorders (i.e. cerebrovascular accident, dementia, seizures, psychiatric disorders)
- Relevant hepatic disease (Child B or higher)
- Regular use of medication that affects the central nervous system (i.e. benzodiazepines, antidepressants, antipsychotics, antiepileptic drugs)
- Use of alpha-agonists or beta-blockers
- Overt signs of alcohol abuse
- Use of preoperative benzodiazepines (on the day of the study)
- Overt signs of drugs abuse
- Beta Blockers eye drips

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Absolute blood pressure, heart rate, cardiac output, cerebral and tissue<br /><br>oxygenation and 2) changes in blood pressure, heart rate, cardiac output,<br /><br>cerebral and tissue oxygenation from baseline (awake), which will be recorded<br /><br>during standardized induction and maintenance of anesthesia using 4 different<br /><br>combinations of remifentanil and propofol.<br /><br>3) Total dose of atropine and ephedrine required to maintain heart rate ><br /><br>40/min and mean arterial blood pressure > 50 mmHg, respectively.<br /><br>4) Probability of tolerance of laryngoscopy, which will be tested after<br /><br>induction and during a steady-state maintenance of anesthesia.</p><br>

Secondary Outcome Measures