High Mean Arterial Pressure Target Improves Microcirculation in Septic Shock Patients With Previous Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Mean Arterial Pressure
研究概览
简要总结
We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
详细描述
The effect of mean arterial pressure (MAP) titration to higher level on microcirculation in septic shock patients with previous hypertension remains unknown. Our goal was to assess the effect of MAP titration to patients' usual level on microcirculation in septic shock patients with previous hypertension. We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with septic shock for less than 24 hours
- •Fluid resuscitation was performed according to the guideline for treating septic shock to maintain the central venous pressure (CVP) for more than 8 mm Hg and central venous oxygen saturation for more than 70%
- •Patients requiring norepinephrine (NE) to maintain a MAP of 65 mm Hg. Septic shock patients with fluid resuscitation after CVP > 8mmHg and mean blood pressure > 65 mmHg
排除标准
- •Pregnancy
- •Age < 18 years
- •Inability to acquire the usual level of MAP
- •Refusal of consent by the patient or relative
- •Participation in other trials during the last three months
- •Hypertensive patients without hypertension treatment
结局指标
主要结局
Mean Arterial Pressure
时间窗: Target MAP stabilization for 30 min
As chronic hypertensive patients were supposed to have undergone more blood pressure measurements in daily life than non-hypertensive ones, the averaged MAP acquired from patients' physical examination records of the last two years was registered and assumed as patients' usual level of MAP and target MAP. If patients' medical records were incomplete, a detailed enquiry about the target MAP to their next kin was performed. After stabilization for 30 min, basal measurements including hemodynamic and microcirculatory measurements were taken, 20 min apart, the NE doses were increased to titrate MAP to the target level. Patients were allowed to stabilize for 30 min before taking new measurements.
次要结局
- Perfused Vessel Density(Target MAP stabilization for 30 min)
研究者
Jingyuan,Xu
ZhongDa Hospital
Southeast University, China