Antibiotic regimens for treatment of resistant pneumonia

Phase 2

• Conditions: Condition 1: Pneumonia. Condition 2: Pneumonia. Condition 3: Pneumonia.; Pneumonia due to Klebsiella pneumoniae; Pneumonia due to Pseudomonas; Pneumonia due to other aerobic Gram-negative bacteria

• Registration Number: IRCT201509213449N19
• Lead Sponsor: Vice Chancellor for Research, Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Adult patients (18-65 years old) with ventilator-associated pneumonia due to multidrug resistant gram negative organisms will be included.
Exclusion criteria: Infection with gram negative organism with meropenem MIC > 8 µg/ml; Infection with gram negative organism with colistin MIC > 2 µg/ml; Patients with an allergy to each of two antibiotic regimens

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical response of pneumonia to treatment regimen. Timepoint: At day 2, day 7, day 17. Method of measurement: Evaluation of fever, blood cells, pulmonary secretions, oxygenation status.;Microbiological response to treatment regimen. Timepoint: At day 2, day 7. Method of measurement: Tracheal secretion culture.;Clinical outcome of patients. Timepoint: day 7, day 14, day 21, day 28. Method of measurement: 28 days patients' follow-up.;Duration of ICU stay. Timepoint: day 7, day 14, day 21, day 28. Method of measurement: 28 days patients' follow-up.