Functional Prognosis in Patients With Ischemic Stroke According to the Therapeutic Strategy Used

Not Applicable

Completed

• Conditions: Ischemic Stroke
• Interventions: Biological: prise de sang; Other: quality of life questionnaire

• Registration Number: NCT02856074
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

The current management of ischemic stroke is based on different strategies that may be combined: intravenous thrombolysis in a stroke ICU, intravenous thrombolysis in a telemedicine procedure, endovascular thrombectomy. Given this now rich therapeutic arsenal, it seems necessary to evaluate practices in local care in the field and the impact of these on the prognosis of ischemic stroke victims. The aim of this observational study is to compare these different care practices without interfering with the choice of strategy.

A blood sample will also be taken at different times to study the value of growth differentiation factors (GDF) 8, 11 and 15, and Brain-derived Neurotrophic Factor as prognostic biomarkers

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-13
• Study First Submitted: 2016-08-02
• Study First Submitted QC: 2016-08-03
• Study First Posted: 2016-08-04
• Primary Completion: 2019-06-11
• Study Completion: 2020-06-01
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-24
• Last Update Posted: 2021-11-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 821

Inclusion Criteria

• Patients with symptomatic ischemic stroke defined according to WHO criteria and treated by intravenous thrombolysis at the stroke ICU at Dijon CHU, intravenous thrombolysis by telemedicine with subsequent transfer to the Dijon stroke ICU, and/or endovascular thrombectomy at Dijon CHU)
• Patients aged over 18 years.
• Patients who have provided written informed consent to take part in the study.

Exclusion Criteria

• Patients who refuse to take part in the study.
• Subjects in custody.
• Patients (or a person of trust) who cannot be contacted by telephone during the follow-up.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Ischemic stroke patients	prise de sang	-
Ischemic stroke patients	quality of life questionnaire	-

Primary Outcome Measures

Name	Time	Method
Rate of handicap	6 months

Secondary Outcome Measures

Name	Time	Method
Serum levels of biomarkers of stress	Changes compared with baseline levels at Day 1, Day 3, Day 7

Trial Locations

Locations (1)

CHU Dijon Bourgogne; 🇫🇷 Dijon, France