Subproject 2: Musculoskeletal simulations towards a subject-specific spino-pelvic load transfer predictio

Recruiting

Conditions: M54.5
Low back pain

Registration Number: DRKS00028773

Lead Sponsor: BIH - Julius Wolff Institut für Biomechanik und Muskuloskeletale Regeneration

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 320

Inclusion Criteria

Written consent to participate in the study
Asym. (no LBP) and symptomatic (chronic LBP) Caucasian women and men aged 18-64 years.
Pain duration >12 weeks
Pain location: lumbar-pelvic region

Exclusion Criteria

Professional, competitive and elite athletes
Acute infections
Abuse of addictive substances
Pregnancy
BMI >28 kg/m2
Central or peripheral neurological impairments (e.g., spinal cord injuries, radicular symptoms, sensory deficits)
Irritated, inflamed and infected tissue in the measurement areas of the back
Fractures of the spine
Osteoporosis
Tumor diseases and bone metastases
Previous operations on the spine
Heavy drug therapy (opioids, muscle relaxants, antiepileptic drugs)
Use of long-acting antihistamines and/or systemic glucocorticoids and/or immunosuppressive drugs
Rheumatic diseases
Active systemic diseases (e.g., tuberculosis, collagenosis, multiple sclerosis, autoimmune diseases, acquired immune deficiency syndrome)
Internal diseases that pose a potential risk to study participants during measurements (e.g., coronary heart disease) and/or influence findings
Poor posture or abnormalities of the lower extremities
Advanced disc degeneration

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The clinical parameter used to test the hypotheses is the (physical) compression force of the lower lumbar spine segments.

Secondary Outcome Measures

Name	Time	Method
Spinal degeneration (objective MRI classification osteochondrosis according to Modic, spondyloarthritis according to Fujiwara, disc degeneration according to Pfirrmann, spinal stenosis according to Schizas, hip osteoarthritis, hip dysplasia, muscle status) at T0.<br>Lower back pain (questionnaire: adapt. von Korff pain scale; Von Korff, Ormel, Keefe, & Dworkin, 1992) at T0<br>Pain grading lower back pain (questionnaire: adapt. von-Korff pain scale; Von Korff, Ormel, Keefe, & Dworkin, 1992) at T0<br>Impairment due to back pain (Roland-Morris-Disability Scale, Roland & Morris, 1983) at T0<br>Health-related quality of life (SF36) at T0.<br>