Abnormally High Parathyroid Hormone Levels Worsens Outcomes in Vitamin D Depleted Critical Care Patients
- Conditions
- Registration Number
- NCT06711874
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
This study aims to investigate the impacts of abnormally elevated PTH levels on clinical outcomes among critically ill patients with vitamin D depletion.
- Detailed Description
This study is a secondary analysis of data from a previous multicentre, prospective, observational cohort study (REC No: 201805087RINB) examining vitamin D deficiency prevalence and outcomes in critical care. From the previously enrolled 651 critically ill patients admitted to medical and surgical intensive care units (ICUs), those enrolled within 48 hours o...
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 320
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality From enrollment to day 90 Survival on day 28, survival to hospital discharge
- Secondary Outcome Measures
Name Time Method Acute Physiology and Chronic Health Evaluation II (APACHE II) score From enrollment to day 90 Apache II Score is a severity-of-disease classification system based on a number of laboratory values and patient signs taking both acute and chronic disease into account. An integer score from 0 to 71 with higher scores meaning a worse outcome.
Sequential Organ Failure Assessment (SOFA) score From enrollment to day 90 SOFA score is a scoring system that assesses the performance of several organ systems in the body (neurologic, blood, liver, kidney, and blood pressure/hemodynamics) and assigns a score based on the data obtained in each category. An integer score from 0 to 24 with higher scores meaning a worse outcome.
ICU length of stay From enrollment to day 90 The days patients stays in ICU
Laboratory parameters From enrollment to day 90 Serum levels of 25-hydroxyvitamin D (25(OH)D), calcium, parathyroid hormone (PTH), cortisol
Trial Locations
- Locations (1)
National Taiwan University Hospital
🇨🇳Taipei, Taiwan