Association Between Nasal Provocation Test With Lysine-Acetylsalicylate(ASA) and Clinical Diagnosis in Patients With Aspirin/Nonsteroidal Anti-Inflammatory Drugs(NSAIDs) and/or Acetaminophen Immediate Sensitivity Reactions

Chulalongkorn University2 个研究点分布在 1 个国家目标入组 34 人开始时间: 2008年11月最近更新: 2010年11月18日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Chulalongkorn University
入组人数: 34
试验地点: 2
主要终点: Symptom scores and/or acoustic rhinometry result upon Lysine-ASA nasal provocation test in patients with history of mucocutaneous or respiratory symptoms from NSAIDs

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study aims to compare the efficacy of nasal provocation test with Lysine-Acetylsalicylate in patients with history of NSAIDs hypersensitivity between mucocutaneous symptoms and respiratory symptoms and laboratory outcomes.

研究设计

研究类型: Interventional
干预模型: Parallel
主要目的: Diagnostic
盲法: None

入排标准

年龄范围: 15 Years 至 70 Years（Child, Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•Patients with history of ASA/NSAIDs hypersensitivity with mucocutaneous symptoms and/or respiratory symptoms

排除标准

•Patients who cannot discontinue drugs before the test as follow
•Nasal corticosteroids/Oral corticosteroids/Leukotriene modifiers for 1 week
•Short-acting antihistamines for 3 days
•Nasal a-mimetics/Oral a-mimetics/Local cromones for 24 hours
•Contraindicated for nasal provocation test: pregnant, exacerbation of allergic rhinitis/asthma, having upper respiratory tract infection within 2 weeks prior to the test, having nose surgery within 8 weeks prior to the test, having severe systemic disease(s)
•Having factors interfere nasal provocation test with Lysine-ASA such as massive nasal polyp, nasal septal perforation, total nasal obstruction at least 1 nostril

结局指标

主要结局

Symptom scores and/or acoustic rhinometry result upon Lysine-ASA nasal provocation test in patients with history of mucocutaneous or respiratory symptoms from NSAIDs

时间窗: 5 months

次要结局

Correlation between clinical manifestations and laboratory results (basophil activation test, etc.)(5 months)

研究者

发起方

Chulalongkorn University

申办方类型

Other

研究点 (2)

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