Use of Thalidomide in Patients With Arachnoiditis

Phase 2
Completed
Conditions
Registration Number
NCT00284505
Lead Sponsor
Washington University School of Medicine
Brief Summary

This pilot study will evaluate whether thalidomide decreases pain in patients with arachnoiditis.

Detailed Description

Arachnoiditis, a neuropathic disease caused by inflamation of the arachnoid membrane that surrounds and protects the spinal nerves,can result in a debilitating state that is characterized by numbing and tingling, stinging and burning in the lower back or legs, and possible muscle cramps, twitching and spasms. Current treatments are not always effective in tr...

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
3
Inclusion Criteria
  • Radiographically confirmed Arachnoiditis
  • Involvement of the lower limb(s)
Read More
Exclusion Criteria
  • Subjects with baseline peripheral neuropathy to include diabetic neuropathy and other metabolic or toxic neuropathies.
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Primary Outcome Measures
NameTimeMethod
1. To evaluate the change in pain as measured by the McGill Pain Questionnaire, short form, (SF-MPQ) and consumption of adjuvant opioid medications in three patients with arachnoiditis who receive thalidomide.
2. To evaluate the change in physical functionality as measured by the Roland-Morris Low Back Pain and Disability Questionnaire in three patients with arachnoiditis who receive thalidomide.
Secondary Outcome Measures
NameTimeMethod
1. To measure change in the patient's health status as measured by the SF36 in three patients with arachnoiditis who receive thalidomide.

Trial Locations

Locations (1)

Washington University Pain Management Center

🇺🇸

St. Louis, Missouri, United States

© Copyright 2024. All Rights Reserved by MedPath