Use of Thalidomide in Patients With Arachnoiditis
Phase 2
Completed
- Conditions
- Registration Number
- NCT00284505
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
This pilot study will evaluate whether thalidomide decreases pain in patients with arachnoiditis.
- Detailed Description
Arachnoiditis, a neuropathic disease caused by inflamation of the arachnoid membrane that surrounds and protects the spinal nerves,can result in a debilitating state that is characterized by numbing and tingling, stinging and burning in the lower back or legs, and possible muscle cramps, twitching and spasms. Current treatments are not always effective in tr...
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3
Inclusion Criteria
- Radiographically confirmed Arachnoiditis
- Involvement of the lower limb(s)
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Exclusion Criteria
- Subjects with baseline peripheral neuropathy to include diabetic neuropathy and other metabolic or toxic neuropathies.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method 1. To evaluate the change in pain as measured by the McGill Pain Questionnaire, short form, (SF-MPQ) and consumption of adjuvant opioid medications in three patients with arachnoiditis who receive thalidomide. 2. To evaluate the change in physical functionality as measured by the Roland-Morris Low Back Pain and Disability Questionnaire in three patients with arachnoiditis who receive thalidomide.
- Secondary Outcome Measures
Name Time Method 1. To measure change in the patient's health status as measured by the SF36 in three patients with arachnoiditis who receive thalidomide.
Trial Locations
- Locations (1)
Washington University Pain Management Center
🇺🇸St. Louis, Missouri, United States