NCT03684876终止不适用
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- change in renal glomerular filtration before and 6 hours after use of diurectic
研究概览
简要总结
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics
详细描述
The study will compare cardiac and renal data before and 6 hours after use of diuretic
- Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output
- Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient undergoing elective cardiac surgery under cardiopulmonary bypass
排除标准
- •heart transplantation
- •use of vasopressor
- •chronic renal disease (DGF under 30 ml min-1)
- •endocarditis
- •patient under ECLS or CPIA
- •patient under 18-year-old
结局指标
主要结局
change in renal glomerular filtration before and 6 hours after use of diurectic
时间窗: at baseline (o hours) and 6 hours after use of diuretic
change in renal glomerular filtration before and 6 hours after use of diurectic
次要结局
未报告次要终点
研究者
研究点 (2)
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