A Comparative evaluation of Platelet Rich Fibrin Matrix (PRFM) AND Coronally Advanced Flap(CAF) with and without Peripheral Blood Mesenchymal Stem Cells (PBMSCs) in the surgical management of Gingival Recession Type 1 – A Split-mouth Randomised Controlled Trial.

Phase 4

Conditions: Health Condition 1: K060- Gingival recession

Registration Number: CTRI/2024/02/062289

Lead Sponsor: DR JEEVIKA A DAS

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Systemically healthy male and female subjects in the age group of 20-50 years, with gingival recession type 1 defect on at least 2 adjacent teeth, with no radiographic evidence of interdental bone loss.

Probing pocket depth = 3 mm.

Adequate width of attached gingiva.

Exclusion Criteria

Pregnant/lactating women.

Patients on drug therapy known to affect the number and function of platelets in the past 3 months.

Patients with abnormal platelet count or having disease affecting platelet count.

Patients with immunologic diseases.

Current and former smokers.

Patients having a history of periodontal therapy in the last 6 months.

Any other contraindications for periodontal surgery.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Plaque Index (PI): Silness and Loe (1964) <br/ ><br>2. Gingival Index (GI): Loe and Silness (1963) <br/ ><br>3. Vertical Component Of The Gingival Recession (VGR) <br/ ><br>4. Horizontal Component Of The Gingival Recession (HGR) <br/ ><br>5. Probing Pocket Depth (PPD) <br/ ><br>6. Clinical Attachment Level (CAL) <br/ ><br>7. Width of Attached Gingiva (WAG) <br/ ><br>8. Width of Keratinized Gingiva (KG) <br/ ><br>9. Gingival Thickness (GT) <br/ ><br> <br/ ><br>Timepoint: Baseline, 3 months, 6 months, 1 year, and 2 year.

Secondary Outcome Measures