The Effect of Exercise Training on Gait and Quality of Life in Parkinson's Disease

Not Applicable

Terminated

• Conditions: Parkinson's Disease
• Interventions: Other: Walking on treadmill; Other: Control group

• Registration Number: NCT01701128
• Lead Sponsor: Laval University

Brief Summary

The project aims to evaluate the effects of 24 weeks of treadmill training (TT), with and without a strengthening component, on functional mobility, gait and quality of life in patients with Parkinson's disease (PD). The rationale for a study of this type stems from the hypothesis that treadmill training may act as an external "pacemaker" and enhance some properties of gait. There is a need for larger scale randomized controlled trials comparing the effects of treadmill training to control groups that receive similar amounts of attention. To date, no study has combined TT and muscle strengthening, likely the optimal form of therapy. A kinesiologist supervises the training, 3 times per week, for a total of 72 one-hour exercise sessions. It is hypothesized that at the end of 6 months, treadmill training will considerably improve walking parameters and the well being of people with PD.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10
• Primary Completion: 2011-06
• Study Completion: 2012-03
• Status Verified: 2012-09
• Study First Submitted: 2012-09-18
• Study First Submitted QC: 2012-10-03
• Last Update Submitted: 2012-10-03
• Study First Posted: 2012-10-04
• Last Update Posted: 2012-10-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Diagnosis of idiopathic Parkinson's disease
• Stage of II or less on Hoehn and Yahr scale

Exclusion Criteria

• Having musculoskeletal impairments or having excessive pain in any joint that could limit participation in exercise program
• Dementia (MMSE<24)
• Having balance problems
• Live beyond 45 minutes from Laval University

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Speed TT	Walking on treadmill	Walk on treadmill with progressive increases in speed
Mixed TT	Walking on treadmill	Walk on treadmill with progressive increases in speed and incline
Control	Control group	Light-intensity exercise group, work flexibility and coordination

Primary Outcome Measures

Name	Time	Method
Change in Gait speed	Baseline, 3 and 6 months	This measure was recorded using the GAITrite system
Change in Endurance walking	Baseline, 3 and 6 months	This measure was recorded using the 6-minutes walk test
Change in Quality of life	Baseline, 3 and 6 months	This measure was recorded using PDQ-39

Secondary Outcome Measures

Name	Time	Method
Change in Postural Balance	Baseline, 3 and 6 months	This measure was recorded using force platform PRO Balance Master®
Change in Spatiotemporal parameters of walking	Baseline, 3 and 6 months	This measure was recorded using the GAITrite system
Change in Cognitive impairment	Baseline, 3 and 6 months	This measure was recorded using Mini-Mental State Examination
Change in Fear of falling	Baseline, 3 and 6 months	This measure was recorded using the ABC Scale
Change in Depression and anxiety level	Baseline, 3 and 6 months	This measure was recorded using BDI-II
Change in Effects of symptoms and motor impairment	Baseline, 3 and 6 months	This measure was recorded using the UPDRS

Trial Locations

Locations (2)

Laval University; 🇨🇦 Quebec, Canada

Quebec Memory and Motor Skills Disorders Research Center; 🇨🇦 Quebec, Canada