Prospective Registry Trail COMparing Stereotactic Body Radiotherpy (SBRT) to Conventional PAlliative RadioTherapy (CRT) in Patients With Spinal Metastases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Describe physician decision-making when making a recommendation for SBRT vs CRT in spine metastasis patients requiring radiation.
研究概览
简要总结
This is a single institutional registry-based, prospective, observational study to describe radiation oncologists' decision making during evaluation of patients and to compare real-world outcomes of SBRT vs CRT.
A registry-based trial involves observing the effect of something without manipulating it.
详细描述
The purpose of this study is to study the differences between CRT and SBRT. The investigator's are assessing radiation oncologists' decision-making during the evaluation of patients with spinal metastases by requesting radiation oncologists complete a questionnaire. Additionally, the investigator's will compare outcomes, including local progression, pain response and overall survival between SBRT and CRT. By collecting this information, the investigator's will develop an evidence-based algorithm that may be used to support medical decision-making for others with spinal metastases in the future.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults 18 years of age or older.
- •Patients seen at the Princess Margaret Cancer Centre with painful spinal metastases amenable to radiation treatment.
- •Confirmation of diagnosis: a) Known/documented prior histological cancer diagnosis
- •Able to provide written consent
- •ECOG performance status 0-3
排除标准
- •Prior radiotherapy, with fields overlapping, resulting in excessive doses to organs at risk
- •Lymphoma, myeloma or germ cell malignancies
研究组 & 干预措施
Stereotactic Radiotherapy (SBRT)
Standard of care stereotactic radiotherapy.
干预措施: Radiotherapy (Radiation)
Conventional Radiotherapy (CRT)
Standard of care conventional radiotherapy.
干预措施: Radiotherapy (Radiation)
结局指标
主要结局
Describe physician decision-making when making a recommendation for SBRT vs CRT in spine metastasis patients requiring radiation.
时间窗: 2 years
Physician's decision making will be assessed by a questionnaire containing 6 questions, including questions on variations of practice and the role of a number of factors that may influence a physician's recommendation for spine metastasis patients requiring radiation (SBRT vs CRT).
次要结局
- Assess local progression free survival.(2 years)
- Measure pain response(2 years)
- Assess adverse events(2 years)
- Measure overall survival(2 years)