The Use of Liposomal Bupivacaine in TAP Blocks for Women Undergoing Cesarean Section
Overview
- Phase
- Phase 2
- Intervention
- TAP block w Liposomal bupivacaine
- Conditions
- Pain
- Sponsor
- Milton S. Hershey Medical Center
- Locations
- 1
- Primary Endpoint
- Postoperative narcotic use
- Status
- Withdrawn
- Last Updated
- 6 years ago
Overview
Brief Summary
This present investigation aims to determine whether a transversus abdominous plane(TAP) block, utilizing liposomal bupivacaine (Exparel), at the conclusion of a cesarean section decreases post-operative pain. The hypothesis is that performance of the TAP block with liposomal bupivacaine will decrease post-operative narcotic use.
Investigators
Jaimey M. Pauli, MD
OB/GYN Resident
Milton S. Hershey Medical Center
Eligibility Criteria
Inclusion Criteria
- •Patients \>18 years of age
- •Scheduled cesarean section with or without bilateral tubal ligation
- •Planned performance of a Pfannenstiel incision
- •Patients are schedule to have a cesarean section with a member of the Women's Health or Maternal and Fetal Medicine Departments at Penn State University Hershey S. Medical Center
Exclusion Criteria
- •History of opioid use
- •History of chronic pain syndrome
- •Use of general anesthesia during cesarean delivery
- •Postoperative SICU admission
- •Postpartum hemorrhage (defined as an Estimated Blood Loss of greater then 1,000mL upon completion of the cesarean section)
Arms & Interventions
Intervention-Tap block w Liposomal bupivacaine
After completion of surgery w closure of skin incision a TAP block will be performed. On confirmation of entering the fascial plane, Liposomal bupivacaine 0.33% (10 ml diluted to 20 ml using sterile normal saline) will be injected after negative aspiration. That will complete the intervention. 20 patients will be in this arm
Intervention: TAP block w Liposomal bupivacaine
Placebo- Tap block w normal saline
After completion of surgery with closer of skin incision a TAP block will be performed. On confirmation of entering the fascial plane, 20cc of Normal saline will be injected after negative aspiration. That will complete the intervention. 20 patients will be in this arm
Intervention: TAP block w normal saline
Outcomes
Primary Outcomes
Postoperative narcotic use
Time Frame: initial 48 hours postoperatively
Patient use of standard postoperative narcotics (percocet) will be measured.
Secondary Outcomes
- Subjective pain scores using 1-10 VAS system(initial 48 hours postoperatively)