Memory, Epilepsy and Brain Stimulation: Oscillatory Patterns During Real-world Navigation and Free Recall in Chronically Implanted Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Proportion of words recalled with and without stimulation.
研究概览
简要总结
This study is designed to identify brain activity associated with good memory in subjects with a chronically implanted RNS® device and to study the effects of therapeutic stimulation for epilepsy on memory. This will be accomplished through analysis of ECoG data collected during memory encoding for short and long-term free recall as well as during navigation tasks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •able to give informed consent
- •18 years of age or older
- •Diagnosis of epilepsy
- •Implanted RNS® device and receiving therapeutic stimulation for epilepsy.
- •Capable of completing experimental tasks in the judgment of the Principal Investigator
排除标准
- •RNS® Neurostimulator implanted within 3 months of experimental tasks.
研究组 & 干预措施
RNS® Neurostimulator
Subjects with pharmaceutically intractable seizures who have been implanted with a RNS® Neurostimulator.
干预措施: electrical stimulation (Other)
结局指标
主要结局
Proportion of words recalled with and without stimulation.
时间窗: 30 days
This study is designed to study the effects of therapeutic stimulation for epilepsy on memory. This outcome will be assessed by free recall language and memory tasks.
次要结局
- Changes in the power spectrum of ECoG data with an increase of recalled words.(30 days)
- Proportion of words recalled during times of interictal activity.(30 days)
- Proportion of navigation challenges recalled successfully with and without stimulation.(30 days)
研究者
Barbara Jobst
Dr.
Dartmouth-Hitchcock Medical Center