Use of 18F-FLT Positron Emission Tomography to Evaluate the Suspicious Findings on Mammography and Breast Ultrasound: A Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- 18F-FLT
- Conditions
- Breast Neoplasms
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound, using the pathologic result of biopsy as gold standard.
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose: To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound.
Detailed Description
1. To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound, using the pathologic result of biopsy as gold standard, and to determine whether 18F-FLT PET can increase the specificity in breast lesion diagnosis and thus reduce the unnecessary biopsy. 2. To evaluate whether 18F-FLT PET is a cost-effective imaging modality for breast cancer diagnosis.
Investigators
National Taiwan University Hospital
National Taiwan University Hospital
National Taiwan University Hospital
Eligibility Criteria
Inclusion Criteria
- •Women aged between 20 to 80 years
- •women who have localized findings on mammography and / or ultrasound and will receive biopsy.
- •The lesions on the conventional imaging measure \>=1cm
- •WBC count \>=3000/L, or platelet\>=75,000/L
- •Liver function, AST or ALT \< 78 U/L
- •Renal function, Creatinine \< 2.0 mg/dl.The laboratory examinations should be performed within 4months before our study.
Exclusion Criteria
- •Pregnant women or who are planning to be pregnant.
- •Known cancers in other organs.
- •Women who are not able to cooperate with the PET/CT examination.
Arms & Interventions
18F-FLT
18F-FLT PET for Suspicious Findings on Mammography and Breast Ultrasound.
Intervention: 18F-FLT
Outcomes
Primary Outcomes
To investigate the diagnostic accuracy of 18F-FLT PET for the suspicious lesions on mammograms and ultrasound, using the pathologic result of biopsy as gold standard.
Time Frame: The biopsy procedures will be scheduled as soon as possible and should be finished within 2 months after 18F-FLT PET.