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临床试验/NCT06680908
NCT06680908已完成不适用

Investigating the Effects of Combined Mental and Physical Stress

Texas State University1 个研究点 分布在 1 个国家目标入组 56 人开始时间: 2024年1月20日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
56
试验地点
1
主要终点
Salivary secretory IgA

研究概览

简要总结

The goal of this clinical trial is to examine the effects of combined mental and physical stress on biomarkers of stress in healthy college aged individuals. The mental stress performed is a virtual reality active shooter drill that lasts ~3 minutes, and the physical stressor is a Ruffier squat test accompanied with jump rope, in order to examine the effects of combined stress versus physical stress alone. The main question to answer is:

  • What is the impact of combined stress in comparison to a single stressor on markers of subjective and biological stress?

详细描述

This study randomly assigned subjects to 2 groups; group one was assigned to experience the Ruffier squat test and jump rope, a physical stressor, alone. While group two was assigned to a dual stressor, the Ruffier squat test and jump rope, followed by the virtual reality active shooter drill (VR-ASD). The stress tasks marked the midway point in the study, prior to and following the stress task, researchers collected heart rate (HR), state inventory assessment (SAI), and a salivary sample in order to assess differences in perceived and physiological stress levels.

All procedures from this project were reviewed and approved by the University Institutional Review Board.

The experimental procedures began upon arrival to the testing site where the subjects read and signed the informed consent document, had their body composition measurements taken by the inbody, as well as height taken, they were then exported to the gymnasium where they were instructed to rinse their mouth with water and rest. There was 4 collection periods in this study, where a SAI, HR, and saliva sample was taken; 1) 30 minutes pre exercise test 2) immediately pre exercise test 3) 5 minutes post exercise test 4) 30 minutes post exercise.

Virtual Reality- Active Shooter Drill (VR-ASD):

The VR-ASD is a virtual reality simulation that required the subject to wear a VR headset, carry a Glock 17 training pistol, and navigate the VR environment by physically moving on their own without interruption. The VR was performed in an open gymnasium, much larger than the scenario, to allow for ample room to roam the scenario. Following a familiarization period, the subject is then told they are a responding officer to an active shooter where they will be asked to find and eliminate the target. The subject then physically walked down a 10-foot hallway in VR where they encountered 2 victims of the shooting. One of the victims has traumatic injuries, while the other victim runs out of the room with the shooter with gunshot wounds to their arm and leg. Once the subject reaches the room with the shooter, they will observe a victim with a traumatic head injury, and the shooter firing his handgun at the last victim. If the subject hadn't fired their weapon at this point, the shooter would then begin open firing at the participant. Once the shooter had been shot by the participant, the shooter fell to the ground and the scenario ended.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Other

入排标准

年龄范围
18 Years 至 39 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • apparently healthy, aged 18-39
  • free from any known cardiovascular or metabolic diseases,
  • free from any major stressors within the last 30 days such as birth of a child, abortion, or divorce.

排除标准

  • subjects are required to not have a history of motion sickness, or vertigo
  • not previously diagnosed with a brain injury or epilepsy, asthma, or currently taking psychological medication

结局指标

主要结局

Salivary secretory IgA

时间窗: Up to 6 months

SIgA is a marker of immune function and salivary SIgA concentrations tend to increase when exposed to stress

Salivary alpha amylase

时间窗: Up to 6 months

salivary alpha amylase is an enzyme involved in digestive processes. Amylase concentration in saliva have been shown to reflect sympathetic stress. Thus, as sympathetic stress increases, salivary amylase concentrations tend to increase.

Heart Rate

时间窗: Up to 6 months

heart rate reflects activity from parasympathetic and sympathetic nervous system and increases when exposed to stress

State Anxiety Inventory

时间窗: Up to 6 months

state anxiety inventory is a subjective scale which includes six short statements such as "I feel calm" or "I feel tense" and composite scores of participant responses are used for analysis. Higher values reflect higher subjected anxiety.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Matt McAllister

Associate Professor

Texas State University

研究点 (1)

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