The effect of Dexmedetomidine on myocardial protection in patients undergoing Mitral valve replacement/ repair

Phase 3

Recruiting

Conditions: Evaluation of the effect of adding dexmedetomidine to del-Nido cardioplegia solution on myocardial protection in patients undergoing mitral valve replacement / repair.
Nonrheumatic mitral valve disorders

Registration Number: IRCT20210713051881N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 56

Inclusion Criteria

Candidate patients for mitral valve repair or replacement with ejection fraction above 40%

Exclusion Criteria

History of supraventricular dysrhythmias
History of heart surgery
Nephropathy following the use of contrast agent (CIN)
Persistent respiratory problems
Patients with a history of Stroke and TIA
Patients with a history of Coagulopathy
Use an intra-aortic balloon pump (IABP) before and during surgery
Use vasopressor before surgery
Patient dissatisfaction to participate in the study
The presence of any pathological disorder leading to the release of inflammatory cytokines
Cardiopulmonary arrest before, during and after surgery

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Troponin I Assay. Timepoint: Before entering the operating room, In the first hour, 6 hours later, 12 hours later and 24 hours after entering the Intensive Care Unit. Method of measurement: Blood sample.;Creatinine kinease _MB Assay. Timepoint: Before entering the operating room, In the first hour, 6 hours later, 12 hours later and 24 hours after entering the Intensive Care Unit. Method of measurement: Blood sample.;The rate of urinary output. Timepoint: The first 6 hours, the first 12 hours and 24 hours after the operation. Method of measurement: By catheterization.

Secondary Outcome Measures

Name	Time	Method
CRP level. Timepoint: Before surgery, 6 hours after entering the Intensive Care Unit, 12 hours after and 24 hours after entering the Intensive Care Unit. Method of measurement: Blood sample.;ESR level. Timepoint: Before surgery, 6 hours after entering the Intensive Care Unit, 12 hours after and 24 hours after entering the Intensive Care Unit. Method of measurement: Blood sample.;Inotropic Score. Timepoint: In the Intensive Care Unit. Method of measurement: Inotropic score = ([dopamine + dobutamine]×1) + (milrinone×15) + ([epinephrine + norepinephrine + isoproterenol]×100).