BIA-measured Skeletal Muscle Mass Used to Assess Frailty in Older Gastric Cancer Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastric (Stomach) Cancer
- Sponsor
- Nanjing Medical University
- Enrollment
- 575
- Locations
- 1
- Primary Endpoint
- Skeletal muscle mass
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The primary aim of this study was to quantify the diagnosis of pre-surgical skeletal muscle mass in elderly gastric cancer patients and to analyse its correlation with frailty. The second aim was to investigate whether skeletal muscle mass, or sarcopenia, is associated with mobility and nutritional status, and anxiety and depression. The main questions it aims to answer are whether skeletal muscle mass is significantly associated with frailty and whether it can be used as a brief screening tool for preoperative frailty.
Investigators
Yinning Guo
PhD student
Nanjing Medical University
Eligibility Criteria
Inclusion Criteria
- •diagnosed with gastric cancer by endoscopy or pathology; age \>60 years old; radical gastrectomy was proposed; be able to communicate simply in writing and verbal.
Exclusion Criteria
- •received preoperative radiotherapy or chemotherapy; combined with other sites of malignant tumors; combined with severe heart, liver, lung and renal insufficiency; recent using hormones, immunosuppressants; with physical disabilities.
Outcomes
Primary Outcomes
Skeletal muscle mass
Time Frame: Within 24 hours of admission
Skeletal muscle mass was measured by bioelectrical impedance analysis(BIA) and was classified as sarcopenia if it was less than 7.0 kg/m2 in men and 5.7 kg/m2 in women.
frailty
Time Frame: Within 24 hours of admission and discharge
The Tilburg frailty scale was used to assess the frailty of older people with gastric cancer. The Tilburg frailty scale was compiled by Gobbens et al. The scale contains 15 items in three dimensions of physical, psychological and social frailty. The total score of the scale is 0-15 points and the cut-off value of the total scale was 5, with higher score indicating more severe frailty.
Secondary Outcomes
- Nutritional Status(Within 24 hours of admission and discharge)
- anxiety and depression(Within 24 hours of admission and discharge)