Radiation Treatment Of Bladder Cancer With Tomotherapy/ Intensity Modulated Radio Therapy (IMRT)
- Conditions
- Health Condition 1: null- Muscle Invasive Bladder Cancer
- Registration Number
- CTRI/2009/091/000559
- Lead Sponsor
- Tata Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
?Age > 18 years old: Male and Female
?Histologically proven invasive bladder transitional cell carcinoma
?AJCC clinical stages T2-T4a, Nx or N0, M0
?Thorough evaluation by a urologist and have undergone as thorough a TURBT as is judged safely possible
?KPS>= 70
?Able to tolerate systemic chemotherapy combined with pelvic radiation therapy by the joint agreement of the participating Urologist, Radiation Oncologist and Medical Oncologist.
?Hemoglobin >= 10 mg/dl, WBC >= 3000/ml, Absolute neutrophil count of >= 1800/ml, Platelet count of >= 100,000/mm3, Serum creatinine < 1.5 mg%, Serum bilirubin of 2.0mg%
?Ability to take daily treatment
?Only patients with a solitary, well defined tumour will be considered for the boost protocol
?Protocol treatment to begin a maximum of 30 days following TURBT
Prior pelvic radiation therapy.
? Incontinence, need for cathererisation
?Hydronephrosis attributable to the tumour
? Pregnancy
?Previous malignancy that is likely to interfere with protocol treatment
? Inflammatory bowel disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study is to assess the Dosimetric evaluation of Intensity Modulated Radiotherapy treatment for whole and partial Bladder radiotherapy. , novel Adaptive Radiotherapy Technique and set up errors and Internal organ motion with IGRT.Timepoint: NA
- Secondary Outcome Measures
Name Time Method The secondary outcome of the study is to assess the acute and late toxicity, local control and bladder preservation rate.Timepoint: NA