Acute Kidney Injury and Renal Outcomes for COVID-19 Patients in Intensive Care Units
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection
研究概览
简要总结
The actual COVID-19 epidemy is an unprecedented healthcare problem. Although acute respiratory distress syndrome is the main organ failure, acute kidney injury (AKI) has appeared to be more frequent and more severe than expected. Some data suggested a potential direct renal tropism of the virus, or undirect injury by "cytokine storm".
The aims of this study are:
- To describe incidence, severity and mortality associated with AKI during covid-19 infection in ICU
- To identify specific risk factors for AKI
- To explore pathophysiologic mechanism of AKI during COVID-19 infection
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed COVID-19 infection (by qRT-PCR and/or TDM typical lesion)
- •Needing intensive care
排除标准
- •End Stage Renal Disease patients (with pre-existent dialysis)
- •Intensive care support for less than 72h (transfer in conventional unit or death)
结局指标
主要结局
Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection
时间窗: 7 months
AKI will be defined according with KDIGO guidelines: increase in creatinine of more than 1,5 fold compared to baseline Severe CVOID-19 infection is defined as 1/ confirm COVID-19 infection (by TDM and/or qRT-PCR) 2/ Requirement of ICU support during more than 72h
次要结局
未报告次要终点