Acute Kidney Injury and Renal Outcomes for COVID-19 Patients in Intensive Care Units
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- on Occurrence of Acurate Kidney Injury During Intensive Care Unit
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection
- Last Updated
- 5 years ago
Overview
Brief Summary
The actual COVID-19 epidemy is an unprecedented healthcare problem. Although acute respiratory distress syndrome is the main organ failure, acute kidney injury (AKI) has appeared to be more frequent and more severe than expected. Some data suggested a potential direct renal tropism of the virus, or undirect injury by "cytokine storm".
The aims of this study are:
- To describe incidence, severity and mortality associated with AKI during covid-19 infection in ICU
- To identify specific risk factors for AKI
- To explore pathophysiologic mechanism of AKI during COVID-19 infection
Investigators
Eligibility Criteria
Inclusion Criteria
- •Confirmed COVID-19 infection (by qRT-PCR and/or TDM typical lesion)
- •Needing intensive care
Exclusion Criteria
- •End Stage Renal Disease patients (with pre-existent dialysis)
- •Intensive care support for less than 72h (transfer in conventional unit or death)
Outcomes
Primary Outcomes
Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection
Time Frame: 7 months
AKI will be defined according with KDIGO guidelines: increase in creatinine of more than 1,5 fold compared to baseline Severe CVOID-19 infection is defined as 1/ confirm COVID-19 infection (by TDM and/or qRT-PCR) 2/ Requirement of ICU support during more than 72h