Correlating the cough as a result of fentanyl injection while instituting general anaesthesia with the occurrence of nausea and vomiting after surgery in female patients
Not Applicable
Completed
- Conditions
- Fentanyl-induced cough during general anaesthesia and postoperative nausea and vomiting in female patientsSurgery
- Registration Number
- ISRCTN83969715
- Lead Sponsor
- St. John's National Academy of Health Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 263
Inclusion Criteria
1. Female patients aged 18-59 years
2. American Society of Anaesthesiologists (ASA) physical status 1 and 2
3. Surgery lasting for 1- 3 hours duration under general anaesthesia
Exclusion Criteria
1. History of bronchial asthma or chronic obstructive pulmonary disease
2. Smoking status
3. Respiratory or gastrointestinal infection in the previous 2 weeks
4. Preoperative use of an angiotensin-converting enzyme inhibitor, an antiemetic, a bronchodilator or a steroid
5. History of PONV or motion sickness
6. Laparoscopic surgeries
7. Surgeries for malignant lesions
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Fentanyl-induced cough is defined as the occurrence of any episode of cough within 60 seconds of intravenous fentanyl administration<br> 2. Postoperative nausea and vomiting (PONV) is defined as any degree of nausea or vomiting within the first 24 hours after surgery, recorded on a score of 0, 1, or 2 (0 = no nausea or vomiting, 1 = tolerable nausea or vomiting, and 2 = intractable nausea or vomiting requiring medication)<br>
- Secondary Outcome Measures
Name Time Method There are no secondary outcome measures