Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp

Phase 4

Not yet recruiting

• Conditions: Post Operative Pain; Necrotic Pulp
• Interventions: Other: sodium hypochlorite; Other: Vachellia Nelotica

• Registration Number: NCT06116214
• Lead Sponsor: Cairo University

Brief Summary

The aim of this study is to assess the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction.

Detailed Description

Clinical compare the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction when used as root canal irrigant in necrotic pulp. The post operative pain will be recorded using Numerical rating scale, and the bacterial load reduction will be measured by Bacterial counting using agar culture technique.

Study Timeline

• Study First Submitted: 2023-10-24
• Status Verified: 2023-11
• Study Start: 2023-11
• Study First Submitted QC: 2023-11-02
• Last Update Submitted: 2023-11-02
• Study First Posted: 2023-11-03
• Last Update Posted: 2023-11-03
• Primary Completion: 2024-02
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	sodium hypochlorite	in this group the teeth will be irrigated with 2.5% Sodium Hypochlorite (gold standard)
Experimental group	Vachellia Nelotica	in this group the teeth will be irrigated with 10% V. Nelotica (Herbal irrigant)

Primary Outcome Measures

Name	Time	Method
post operative pain.	At 6, 12, 24, and 48 hours postoperatively (post instrumentation and post obturation)	non=0, mild=1-3, moderate4-6, sever=7-10. Measured and reported by Numerical Rating Scale (NRS). Minimum value=0, maximum value=10, the higher score or value mean a worse outcome.

Secondary Outcome Measures

Name	Time	Method
Bacterial load reduction	1 hour. First sample (S1) will be taken pre-intervention (before chemo-mechanical preparation) and the second sample (S2) will be taken immediately after the intervention (after completion of chemo-mechanical preparation) on the same visit.	Bacterial counting using agar culture technique.