Aberrant receptor expression in thyroid tissue: A role in the pathogenesis of multinodular goiter? A pilot study

Completed

Conditions: (Toxic) Multinodular Goiter
10043739

Registration Number: NL-OMON40001

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

* Informed consent form signed
* Age 18 years and over
* Multinodular goiter, confirmed with thyroid ultrasound
* Subclinical hyperthyroidism, defined as TSH < 0.10 mE/l and free T4 within reference range [10.0 * 23.0 pmol/l]
* T3 level within reference range, i.e. between 1.30 and 2.70 nmol/l

Exclusion Criteria

* Current use of antithyroid drugs
* Treatment with radioactive iodine in history
* Pregnancy. This condition may lead to subtle enlargement of the thyroid gland, secondary to iodine deficiency. All premenopausal female participants will undergo a *-hCG-urine test before inclusion.
* Born and raised in iodine deficient areas, defined as the green and dark green fields in Figure 3 (protocol, p 13) .
* Any medication known to interfere with thyroid hormone metabolism or with the study medication, like amiodarone, beta blockers, neuroleptics, corticosteroids including inhalation steroids, antihistaminics
* Any condition that the investigator feels would interfere with trial participation or evaluation of results

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Endpoint<br /><br>The % increase in total T4, T3 and Free T4, defined as: ([T4/T3/FT4 max *<br /><br>T4/T3/FT4 at baseline]/ T4/T3/FT4 at baseline) x 100%</p><br>

Secondary Outcome Measures