ISRCTN10242790已完成未知
Effects of Bifidobacterium on skin wrinkle, hydration, ransepidermal water loss (TEWL), elasticity and gloss: a randomized, double-blind, placebo controlled, parallel clinical trial
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 160
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Korean female subjects aged between 30 and 60 years.
- •2. Dry skin on cheek (hydration value is below 48 arbirary units [AU] by Corneometer®)
- •3. Skin wrinkles of over grade 3 by DERMAPRO standard photograph
- •4. No chronic or acute disease, including skin disease
- •5. Signed informed consent for the study.
- •6. Cooperative and available for follow-up during the study period
排除标准
- •1. Has consumed probiotics as dietary supplements, food or beverage products during the last 2 weeks
- •2. Pregnant, nursing or planning to become pregnant
- •3. Irritation or symptomatic allergy to food, including ingredients of cosmetic, medical and test products
- •4. Has taken oral or topical antibiotics during the previous 3 months
- •5. Has taken oral retinoid/steroid drugs or topical applications including steroids during previous 6 months
- •6. Has used functional cosmetics for improvement of skin wrinkle, hydration and elasticity within the last 3 months
- •7. Previous interventions at test site (e.g. skin decortications, Botox and other skin treatments)
- •8. Has participated in a previous study without an appropriate intervening period (3 months) between studies
- •9. Has disease which might affect the study (e.g. cardiovascular, kidney, liver, thyroid, gastrointestinal disease, gout)
- •10. Any skin disease (e.g. atopic dermatitis) at test site
- •11. Any chronic disease (e.g. diabetes, asthma, high blood-pressure) or psychiatric disorder (e.g. depression, schizophrenia, alcoholism, drug addiction)
- •12. Take a medicine for treatment of obesity (e.g. antidepressants, anorectics), contraceptives, hormones or diuretics
- •13. Take excessive alcohol (over 30 g alcohol per day)
- •14. Sensitive or hypersensitive skin
- •15. Damaged skin in or around the test area, which includes sunburn, tattoos, scars or other disfiguration on the test area
- •16. Has an abnormal result in screening clinical chemical analysis by medical specialist
- •17. Has any problem which may interfere with the aim of the study as the judgment of the principal investigator
研究者
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