pilot study of medium term effects of Trazodone and Atomoxetine combination on the number of apnea and apnea-hypopnea sleep index in obstructive sleep apnea patients

Tehran University of Medical Sciences0 个研究点目标入组 18 人开始时间: 待定最近更新: 2023年7月25日

试验速览

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•Definite diagnosis of obstructive sleep apnea with AHI>15 in polysomnography
•lack of compliance treatment with CPAP or BIPAP
•either the patient is unwilling to have surgery or they are not candidates for surgery in the opinion of the expert

•commodities' existence (excluding controlled blood pressure, hyperlipidemia and diabetes)
•Taking any medication that leads to changes in the physiology of breathing, sleep / wake and muscles Taking any medication that leads to changes in the physiology of breathing, sleeping / waking and muscles
•any underlying cardiac disease, such as arrhythmia
•Inability to sleep in supine position
•Hypersensitivity to lidocaine, atomoxetine or trazodone
•History of seizures, Panic disorder, Hyperventilation syndrome, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
•any hepatic disease or failure

发起方