study of medium term effects of Trazodone and Atomoxetine combination in obstructive sleep apnea
- Conditions
- obstructive sleep apnea.Obstructive sleep apnea (adult) (pediatric)G47.33
- Registration Number
- IRCT20220607055095N2
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 18
Definite diagnosis of obstructive sleep apnea with AHI>15 in polysomnography
lack of compliance treatment with CPAP or BIPAP
either the patient is unwilling to have surgery or they are not candidates for surgery in the opinion of the expert
commodities' existence (excluding controlled blood pressure, hyperlipidemia and diabetes)
Taking any medication that leads to changes in the physiology of breathing, sleep / wake and muscles Taking any medication that leads to changes in the physiology of breathing, sleeping / waking and muscles
any underlying cardiac disease, such as arrhythmia
Inability to sleep in supine position
Hypersensitivity to lidocaine, atomoxetine or trazodone
Pregnancy
History of seizures, Panic disorder, Hyperventilation syndrome, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
any hepatic disease or failure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Apnea-hypopnea index. Timepoint: after on month medication consumption. Method of measurement: Polysomnography.
- Secondary Outcome Measures
Name Time Method Minimum O2 saturation. Timepoint: once. Method of measurement: pulse oxymetry.