Study of microcirculation in children with Severe Generalized Infection admitted to the IFF-Fiocruz unit of severe patients

• Conditions: on specified septicemias; CID 10 - A41

• Registration Number: RBR-4jzzh5p
• Lead Sponsor: Instituto Fernandes Figueira

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2011-12-16
• Study Start: 2021-03-02
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Children admitted to the unidadae de pacientes graves (UPG) of Instituto Fernandes Figueira (IFF) Fiocruz; ages between one month and 18 years; diagnosis of severe sepsis or septic shock; indication of mechanical ventilation; in the case of control patients children hospitalized for elective minor surgery.

Exclusion Criteria

Children with body mass below 3kg;contraindications to dark field sidestream device (SDF) assessment as severe bleeding in the sublingual mucosa or malformation of the face that prevented the opening of the mouth;contraindications to indirect calorimetry monitoring or factors that decrease the accuracy of the method such as need for mechanical ventilation with inspired oxygen fraction (FiO2) greater than 85%, need for mechanical ventilation with expiratory pressure at the end of expiration (PEEP) greater than 12 cm H2O; escape around the orotracheal tube expressed by the difference between the inspired tidal volume and the expired tidal volume greater than 10%; presence of bronchopleural fistula; need to use other gases in the mixture such as nitric oxide and heliox; use of respirators with continuous flow; continuous hemodialysis and patients with pulmonary disease with chronic hypercapnia; presence of congenital heart disease; shock from other etiologies; liver cirrhosis, cancer; type I diabetes mellitus and autoimmune rheumatological diseases; conditions that cause microvascular derangements which may confound data analysis; indeterminate or unknown diagnosis time of septic shock; children whose parents or legal guardians did not agree or refused to sign the written informed consent.

Study & Design

• Study Type: Observational
• Study Design: Not specified