OCEAN Registry: Obesity and Clock for Elegant Aging Registry 肥胖控制及生理時鐘之研究計畫
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,000
- 试验地点
- 2
- 主要终点
- Body weight
研究概览
简要总结
This study aims to study the relationships between obesity, circadian rhythm, and aging. The investigators set up a prospective cohort registry for morbid obesity, obesity, and normal subjects with annual follow-up. The cohort aims to investigate the pathophysiological, molecular, genetic, and cellular aspects of the relationships between obesity, circadian deregulation, and impacts on aging. Clinical data, questionnaires, biological material, and molecular signatures will be collected and investigated.
详细描述
The objective of this observational study is the follow-up of 2000 adult obesity (BMI ≥ 35 and 24-35 kg/m2) and non-obese subjects with annual follow-up for 10 years. Clinical data, biochemistry, and biological samples (serum, DNA, RNA, white blood cells) will be collected and stored. Adipose tissues will be collected if participants received liposuction, plastic surgery, bariatric surgery, dermatological procedure, intra-abdominal operation, and cardiovascular surgery. Questionnaires will be obtained with special nurse including sleep quality, chronotypes, and circadian activities. During follow up period, major adverse cardiovascular events will be monitored.
The investigators anticipate that the results generated from the study will provide valuable data to a better understanding of the relationships between obesity, circadian rhythm, and aging.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 20 years old
- •Body mass index ≥ 24 kg/m2
- •For normal subjects, Body mass index < 24 kg/m2
排除标准
- •No inform consent
- •Use of steroid medications
- •Severe systemic diseases or organ failure with estimated life expectancy of 6 months or less
结局指标
主要结局
Body weight
时间窗: 10 years
次要结局
- Personal chronotype (biological clock) as assessed by Munich Chronotype Questionnaire(3, 6, 12, and 18 months. 2, 5, and 10 years)
- Major Cardiovascular Adverse Events(3, 6, 12, and 18 months. 2, 5, and 10 years)
- Sleep quality as assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire(3, 6, 12, and 18 months. 2, 5, and 10 years)
研究者
Chao-Yung Wang
Doctor
Chang Gung Memorial Hospital