Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension

• Conditions: Hypertension, Pulmonary; Lung Diseases; Hypertension;Pulmonary;Primary; Chronic Thromboembolic Pulmonary Hypertension; Vascular Diseases
• Interventions: Diagnostic Test: Capnography

• Registration Number: NCT03388476
• Lead Sponsor: University of Giessen

Brief Summary

Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for pulmonary hypertension as an easily measurable and cheap diagnostic tool in patients with suspicion of pulmonary hypertension.

Detailed Description

The disease pulmonary hypertension is due to a remodeling of the lung vessels which results in a change of the exhaled air. This change is measurable with a so called capnograph. The investigators want to measure the breath from patients with and without pulmonary hypertension to detect a cut-off value for the diagnosis pulmonary hypertension.

Patients which have the probably diagnosis pulmonary hypertension and are older than 18 years are investigated. This patients will get an right heart catheterization and a measurement from their exhaled air.

Study Timeline

• Study First Submitted: 2017-12-22
• Study First Submitted QC: 2017-12-22
• Study First Posted: 2018-01-03
• Study Start: 2018-05-02
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-18
• Last Update Posted: 2022-05-19
• Primary Completion: 2030-01-01
• Study Completion: 2035-01-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Age > 18 years, suspicion of pulmonary hypertension, planned or accomplished right heart catheterization

Exclusion Criteria

none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Suspicion of pulmonary hypertension	Capnography	At Patients with suspicion of pulmonary hypertension, which get a right heart catheterization, in the context of the study the exhaled air, precious the endtidal carbon dioxide (CO2), before or after the right heart catheterization will be measured through capnography.

Primary Outcome Measures

Name	Time	Method
Measurement PetCO2	At baseline	Measurement PetCO2 by capnography at rest after or before a right heart catheterization, comparison of the parameter between patients with and without

Secondary Outcome Measures

Name	Time	Method
Establishing a cut-off	At baseline	Establishing a cut-off for the non-invasive diagnosing of pulmonary hypertension, which differs between patients with and without pulmonary hypertension and save patients without the disease before a dispensable invasive right heart catheterization

Trial Locations

Locations (1)

University Clinic Giessen and Marburg; 🇩🇪 Giessen, Hessen, Germany